Bone Loss

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Bone loss is a known and well studied hazard of microgravity^exd.

Low gravity is on of the unanswered questions, 0g has been studied with humans, mice, and other animals. Higher than 1g has been studied with chickens but there have so far been no low-g studies.

One low gravitation study that has been in the works since 2001 is presently working on funding.

This effects can be mitigated on the Moon by exposing the settlers continuously to a centrifuge and with a strong exercise program.

References

Hazards
Physiological/Psychological/Human Factors  Zero or Low Gravity  Physical Environments  Medical Treatment  Fire/Explosion  Toxins  Corrosives  Temperature Extremes  Non-Ionizing Radiation  Ionizing Radiation  Lack of Breathable Atmosphere  Inadequate Food/Water  Improper Pressure